Evolution, and phylogeny of herv-s family in some closely related primates

Evolution, and phylogeny of herv-s family in some closely related primates

Hawnaz Othman Najmalddin, Aso Ahmed Taher , and Shad Arif Mohammed
Department of Biology, Faculty of Science and Education Science, College of Science, University of Sulaimani.   
email: shad.mohammed@univsul.edu.iq


Article info

Original: 21 Apr. 2015
Revised: 23 May 2015
Accepted: 31 May 2015
Published online:  
20 Dec. 2015         

Key Words: 
Cancer cell line

Human endogenous retroviral element S-family (HERV-S) has been present within the human genome as well as various closely related primates. The expression pattern, copy number, chromosomal locations of the proviral element have been extensively studied. Here, we analyse the pol fragment of the HERV-S in human tissues, cancer cell lines and in seven other related primates. Phylogenetic analysis of the HERV-S pol gene suggests division of the family into two groups among the tested species that have arisen throughout the primate evolution by gene duplication as well as other genetic alterations. Also, the tree analysis of human tissues and cancer cells suggest that expression of the chromosome X pol fragment is identical to expression of the pol fragment in cancerous cells more than its relation to the pol sequence on other human chromosomes. To sum up, our data provide a clarification about the dynamic evolutionary characteristics as well as phylogenetic relationships of HERV-S family pol gene in primates.

Kewan Omer,
Dec 22, 2015, 2:40 PM