Synthesis and antimicrobial evaluation activity of some new substituted spiro-thiazolidine, Imidazolinone and azetidine derivatives of 5-Bromo Isatine

Synthesis and antimicrobial evaluation activity of some new substituted spiro-thiazolidine, Imidazolinone and azetidine derivatives of 5-Bromo Isatine


Nabeel S. Othman1, Shlear H. Hasan2 & Kafia M. Surchi3

Suaad ,M.H.Al-Majidi1 & Lawand, H.K  Kaka Hama1 

1 Department of Chemistry, College of Science, Baghdad University, Baghdad, Iraq

E-mail: arina.press@yahoo.com





Article info
Original: 30 Sep. 2014
Revised: 24 Nov. 2014
Accepted: 10 Dec. 2015
Published online:  
             20 March  2015

Key Words:
5-Bromo isatin
Schiff base
Spiro- thiazoildinone 
Spiro Imidazolinone
Spiro-azetidinone
antimicrobial activity. 



Abstract

A series of new 5-BromoIsatin linked to spiro thiazolidinone, Imidazolinone and azetidinone moieties were synthesized. Schiff bases 3-(substituted –imino)-1H-indole-2-one(1-5),which were prepared by condensation 5-bromoisatin with different substituted aromatic amine in the presence of glacial acetic acid and Dimethyl- formamide (DMF) as a solvent. Three routs with different reagents were used for the cyclization of the Prepared Schiff bases,the reagents(2-mercaptoaceticacid,2-aminoaceticacid and monochloroacetylchloride) to form spiro-Thiazolidinone(6-10), spiro-imidazolinone (11-15) and spiro-azetidinone (16-20) derivatives respectively. The structures of the newly synthesized compounds were identified by spectral methods FTIR,1H-NMR. Furthermore the effects of the preparing compounds on some strains of bacteria and one yeast were studied.

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